SNCA Antibody | 7911

SNCA Antibody | 7911 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Homology: Predicted species reactivity based on immunogen sequence: Pig: (100%) , Bovine: (100%)

Immunogen: SNCA antibody was raised against a 19 amino acid peptide near the carboxy terminus of human SNCA.
The immunogen is located within the last 50 amino acids of SNCA.

Research Area: Neuroscience, Apoptosis

Tested Application: E, WB, IHC-P, IF

Application: SNCA antibody can be used for detection of SNCA by Western blot at 1 - 2 μg/ml. Antibody can also be used for Immunohistochemistry starting at 5 μg/mL. For immunofluorescence start at 20 μg/mL.
Antibody validated: Western Blot in human and mouse samples; Immunohistochemistry in rat samples and Immunofluorescence in rat samples. All other applications and species not yet tested.

Specificiy: SNCA antibody is human, mouse and rat reactive. At least three isoforms of SNCA are known to exist.

Positive Control 1: Cat. No. 1412 - Mouse Cerebellum Tissue Lysate

Positive Control 2: N/A

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: Predicted: 12 kDa
Observed: 16 kDa

Validation: N/A

Isoform: N/A

Purification: SNCA antibody is affinity chromatography purified via peptide column.

Clonality: Polyclonal

Clone: N/A

Isotype: IgG

Conjugate: Unconjugated

Physical State: Liquid

Buffer: SNCA antibody is supplied in PBS containing 0.02% sodium azide.

Concentration: 1 mg/mL

Storage Condition: SNCA antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year.

Alternate Name: SNCA Antibody: PD1, NACP, PARK1, PARK4, Alpha-synuclein, Non-A beta component of AD amyloid

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: Alpha-Synuclein (SNCA) is a hallmark of Alzheimer’s disease (1, 2) . It is a cytoplasmic protein that is predominantly expressed in the central nervous system (2) . SNCA reduces neuronal responsiveness to various apoptotic stimuli, leading to the decreased caspase-3 activation. SNCA may be involved in the regulation of dopamine release and transport and induces fibrillization of microtubule-associated protein tau (3) . Defects in SNCA are associated with familial Parkinson’s disease (4, 5) .