SNCA Antibody (C-term) [APR13431G]

SNCA Antibody (C-term) [APR13431G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H, M, Rat, Cynomolgus Monkey

Specificity: This SNCA antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 92-125 amino acids from the C-terminal region of human SNCA.

Cellular Localisation: Cytoplasm. Membrane. Nucleus. Cell junction, synapse. Secreted Note=Membrane-bound in dopaminergic neurons

Molecular Weight: 14460

Clone: Polyclonal

Gene Name: SNCA

Gene ID: 6622

Function: Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores (PubMed:28288128, PubMed:30404828) . Mechanistically, acts by increasing local Ca (2+) release from microdomains which is essential for the enhancement of ATP-induced exocytosis (PubMed:30404828) . Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5 (PubMed:20798282) . This chaperone activity is important to sustain normal SNARE-complex assembly during aging (PubMed:20798282) . Plays also a role in the regulation of the dopamine neurotransmission by associating with the dopamine transporter (DAT1) and thereby modulating its activity (PubMed:26442590) .

Summary: Tissue Location: Highly expressed in presynaptic terminals in the central nervous system. Expressed principally in brain

Form: N/A

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: WB, FC, IHC-P, IHC

Dilution: IHC--1:100~500 IHC-P--1:100~500 FC--1:25 WB--1:1000

Synonyms: Alpha-synuclein, Non-A beta component of AD amyloid, Non-A4 component of amyloid precursor, NACP, SNCA, NACP, PARK1