SNRPC Antibody (C-term) [APR32010G]

SNRPC Antibody (C-term) [APR32010G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This SNRPC antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 133-159 amino acids from the C-terminal region of human SNRPC.

Cellular Localisation: Nucleus {ECO:0000255|HAMAP-Rule:MF_03153, ECO:0000269|PubMed:2136774}

Molecular Weight: 17394

Clone: Polyclonal

Gene Name: SNRPC {ECO:0000255|HAMAP-Rule:MF_03153}

Gene ID: 6631

Function: Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.

Summary: N/A

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB, IHC-P, FC

Dilution: WB--1:1000 IHC-P--1:100~500 FC--1:10~50

Synonyms: U1 small nuclear ribonucleoprotein C {ECO:0000255|HAMAP-Rule:MF_03153}, U1 snRNP C {ECO:0000255|HAMAP-Rule:MF_03153}, U1-C {ECO:0000255|HAMAP-Rule:MF_03153}, U1C {ECO:0000255|HAMAP-Rule:MF_03153}, SNRPC {ECO:0000255|HAMAP-Rule:MF_03153}