SNRPD3 polyclonal Antibody | BS60048

SNRPD3 polyclonal Antibody | BS60048 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human

Application: WB

Application Range: WB: 1:500~1:1000

Background: U1, U2, U4, U5, U6 and U7 are small nuclear ribonucleoproteins (snRNPs) that comprise the spliceosome in eukaryotes. Each UsnRNP contains common Sm proteins B/B', D1, D2, D3, E, F and G. The Sm proteins pair up as D1-D2, B/B'-D3 and E-F-G to form RNA-free hetero-oligomers in the cytoplasm. Sm proteins aid in the cytoplasmic construction of the UsnRNPs by binding to a conserved Sm site on UsnRNA and forming a stable snRNP core complex. Sm D1, D2 and D3 are present in U1, U2, U4/5 and U5 but not U7 snRNPs in human and mouse cells. U7 snRNPs contain Lsm10, an Sm D1-like protein. Autoantibodies produced in patients suffering from systemic lupus erythematosus react predominantly with Sm B/B', D1 and D3. The major linear epitope of these autoantibodies includes the C-terminal RG dipeptide repeats found in Sm D1 and D3.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: SNRPD3 polyclonal Antibody detects endogenous levels of SNRPD3 protein.

Molecular Weight: ~ 15 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: Small nuclear ribonucleoprotein Sm D3; Sm-D3; snRNP core protein D3; SNRPD3

Immunogen: A synthetic peptide corresponding to residues in Human SNRPD3.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: