SNX17 Antibody (N-term) [AMM07910G]

SNX17 Antibody (N-term) [AMM07910G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This SNX17 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 53-82 amino acids from the N-terminal region of human SNX17.

Cellular Localisation: Cytoplasm. Early endosome. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side

Molecular Weight: 52901

Clone: Polyclonal

Gene Name: SNX17

Gene ID: 9784

Function: Critical regulator of endosomal recycling of numerous surface proteins, including integrins, signaling receptor and channels (PubMed:15121882, PubMed:15769472) . Binds to NPxY sequences in the cytoplasmic tails of target cargos (PubMed:21512128) . Associates with retriever and CCC complexes to prevent lysosomal degradation and promote cell surface recycling of numerous cargos such as integrins ITGB1, ITGB5 and their associated alpha subunits (PubMed:28892079, PubMed:22492727) . Also required for maintenance of normal cell surface levels of APP and LRP1 (PubMed:16712798, PubMed:19005208) . Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns (3P) ) (PubMed:16712798) .

Summary: N/A

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Sorting nexin-17, SNX17, KIAA0064