SNX5 Antibody (N-term) [AMM08689G]

SNX5 Antibody (N-term) [AMM08689G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This SNX5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 43-70 amino acids from the N-terminal region of human SNX5.

Cellular Localisation: Endosome. Early endosome Early endosome membrane; Peripheral membrane protein; Cytoplasmic side. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm. Cell projection, phagocytic cup. Cell projection, ruffle. Note=Recruited to the plasma membrane after EGF stimulation, which leads to increased levels of phosphatidylinositol 3, 4-bisphosphate (PdtIns (3, 4) P2) (PubMed:15561769) . Detected on macropinosomes (PubMed:16968745, PubMed:21048941) . Targeted to membrane ruffles in response to EGFR stimulation.

Molecular Weight: 46816

Clone: Polyclonal

Gene Name: SNX5

Gene ID: 27131

Function: Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns (3P) ) or phosphatidylinositol 3, 4-bisphosphate (PtdIns (3, 4) P2) (PubMed:15561769) . Acts in part as component of the retromer membrane- deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable) . Does not have in vitro vesicle-to-membrane remodeling activity (PubMed:23085988) . Involved in retrograde transport of lysosomal enzyme receptor IGF2R (PubMed:17148574, PubMed:18596235) . May function as link between endosomal transport vesicles and dynactin (Probable) . Plays a role in the internalization of EGFR after EGF stimulation (Probable) . Involved in EGFR endosomal sorting and degradation; the function involves PIP5K1C isoform 3 and is retromer- independent (PubMed:23602387) . Together with PIP5K1C isoform 3 facilitates HGS interaction with ubiquitinated EGFR, which initiates EGFR sorting to intraluminal vesicles (ILVs) of the multivesicular body for subsequent lysosomal degradation (Probable) . Involved in E-cadherin sorting and degradation; inhibits PIP5K1C isoform 3-mediated E-cadherin degradation (PubMed:24610942) . Plays a role in macropinocytosis (PubMed:18854019, PubMed:21048941) .

Summary: N/A

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Sorting nexin-5, SNX5