SOCS7 Polyclonal Antibody | BS65853

SOCS7 Polyclonal Antibody | BS65853 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat,Rabbit,

Application: WB,

Application Range: WB=1:500-2000

Background: The eight members of the recently identified Suppressor of Cytokines Signaling (SOCS) family are SOCS1, SOCS2, SOCS3, SOCS4, SOCS5, SOCS6, SOCS7, and CIS. Structurally the SOCS proteins are composed of an N- terminal region of variable length and amino acid composition, a central SH2 domain, and a C-terminal motif called the SOCS box. The SOCS proteins appear to form part of a classical negative feedback loop that regulates cytokine signal transduction. Transcription of each of the SOCS genes occurs rapidly in vitro and in vivo in response to cytokines, and once produced, the various members of the SOCS family appear to inhibit signaling in different ways. SOCS1 and SOCS6 interact with the insulin receptor (IR) when expressed in human hepatoma cells (HepG2) or in rat hepatoma cells overexpressing human IR. SOCS1 and SOCS6 inhibit insulin-dependent activation of ERK1/2 and protein kinase B in vivo and IR- directed phosphorylation of IRS1 in vitro. These results suggest that SOCS proteins may be inhibitors of IR signalling and could mediate cytokine-induced insulin resistance and contribute to the pathogenesis of type II diabetes. SOCS6 and SOCS7 are expressed ubiquitously in murine tissues and SOCS6 knockout mice are growth retarded.

Storage & Stability: Store at 4°C short term. Aliquot and store at -26°C long term. Avoid freeze-thaw cycles.

Specificity: SOCS7 Polyclonal Antibody detects endogenous levels of SOCS7 protein.

Molecular Weight: ~60kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: NAP 4; NAP 4 Fragment; NAP4; Nck Ash and phospholipase C binding protein; Nck Ash and phospholipase C gamma binding protein; Nck associated protein 4; NCKAP4; SH2 domain containing SOCS box protein; SOCS 7; SOCS4; SOCS6; Suppressor of cytokine signaling 7;SOCS7_HUMAN.

Immunogen: KLH conjugated synthetic peptide derived from human SOCS7:171-270/581

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: affinity purified by Protein A

Pathway: