SOD2 polyclonal Antibody | BS91269

SOD2 polyclonal Antibody | BS91269 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Application: WB IHC

Application Range: WB:1:1,000-1:2,000 IHC:1:50-1:200

Background: The superoxide dismutase family is composed of three metalloenzymes (SOD-1, SOD-2 and SOD-3) that catalyze the oxido-reduction of reactive oxygen species (ROS) such as superoxide anion. The SOD-2 precursor is a 222 amino acid protein that is encoded by nuclear chromatin, synthesized in the cytosol and imported posttranslationally into the mitochondrial matrix. Unlike SOD-1, which is a homodimeric cytosolic Cu-Zn enzyme, SOD-2 is a homotetrameric manganese enzyme (also known as MnSOD) that functions in the mitochondrion. ROS are implicated in a wide range of degenerative processes, including Alzheimer’s disease, Parkinson’s disease and ischemic heart disease. Homozygous mutant mice, which lack SOD-2, exhibit dilated cardiomyopathy, accumulation of lipid in liver and skeletal muscle, metabolic acidosis, oxidative DNA damage and respiratory chain deficiencies in heart and skeletal muscle. Polymorphisms in the SOD-2 gene have also been implicated in nonfamilial, idiopathic, dilated cardiomyopathy in humans.

Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: SOD2 polyclonal Antibody detects endogenous levels of SOD2 protein.

Molecular Weight: 21 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: SOD2, Indophenoloxidase B, IPO B, IPOB, Manganese containing superoxide dismutase, Manganese SOD, Manganese superoxide dismutase, Mangano superoxide dismutase, Mn SOD, Mn superoxide dismutase, MNSOD, MVCD6, SOD 2, SOD2, SODM, Superoxide dismutase [Mn] mitochondrial, Superoxide dismutase [Mn], mitochondrial, Superoxide dismutase 2 mitochondrial,

Immunogen: recombinant protein

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: ProA affinity purified

Pathway: G Protein-coupled Receptors Signaling to MAPK Erk,MAPK Erk in Growth and Differentiation Pathway,