SOGA1 Antibody | 7487

SOGA1 Antibody | 7487 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human

Homology: Predicted species reactivity based on immunogen sequence: Mouse: (93%)

Immunogen: SOGA1 antibody was raised against a 16 amino acid peptide near the carboxy terminus of human SOGA.
The immunogen is located within the last 50 amino acids of SOGA1 .

Research Area: Autophagy

Tested Application: E, WB, IF

Application: SOGA1 antibody can be used for detection of SOGA1 by Western blot at 1 - 2 μg/ml.
Antibody validated: Western Blot in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Specificiy: SOGA1 antibody is human specific. At least four isoforms of SOGA1 are known to exist.

Positive Control 1: Cat. No. 1201 - HeLa Cell Lysate

Positive Control 2: Cat. No. 17-001 - HeLa Cell Slide

Positive Control 3: N/A

Positive Control 4: N/A

Positive Control 5: N/A

Positive Control 6: N/A

Molecular Weight: Predicted: 183 kDa
Observed: 200kDa

Validation: N/A

Isoform: N/A

Purification: SOGA1 Antibody is affinity chromatography purified via peptide column.

Clonality: Polyclonal

Clone: N/A

Isotype: IgG

Conjugate: Unconjugated

Physical State: Liquid

Buffer: SOGA1 Antibody is supplied in PBS containing 0.02% sodium azide.

Concentration: 1 mg/mL

Storage Condition: SOGA1 antibody can be stored at 4˚C for three months and -20˚C, stable for up to one year.

Alternate Name: SOGA1 Antibody : SOGA, KIAA0889, C20orf117, SOGA, Protein SOGA1, SOGA family member 1, 80-kDa SOGA fragment

User Note: Optimal dilutions for each application to be determined by the researcher.

BACKGROUND: The recently identified protein suppressor of glucose by autophagy protein 1 (SOGA1) has been found to be involved in the regulation of autophagy (1) . SOGA1 is thought to contribute to adiponectin-mediated insulin-dependent inhibition of autophagy during the activation of adenosine monophosphate kinase (AMPK) (1, 2) . SOGA1 contains an internal signal peptide that enables the secretion of a circulating fragment of SOGA1, providing a surrogate marker for intracellular SOGA1 levels (2) . Knockdown of SOGA1 elevated glucose production in primary hepatocytes indicates that SOGA1 is an inhibitor of glucose production. It thus might be useful as a novel therapeutic target for diabetes (3) .