SORD Polyclonal Antibody | E-AB-53170

SORD Polyclonal Antibody | E-AB-53170 | Gentaur UK, US & Europe Distribution

Type: Polyclonal Antibody

Synonyms: DHSO, L iditol 2 dehydrogenase, L-iditol 2-dehydrogenase, OTTHUMP00000161939, SDH, Sorbitol dehydrogenase 1, Sorbitol dehydrogenase, SORD 1, SORD, SORD1

Application: IHC, ELISA

Reactivity: Human, Mouse

Host: Rabbit

Isotype: IgG

Reserch Areas: Metabolism, Signal Transduction

Background: Sorbitol dehydrogenase (SORD; EC 1.1.1.14) catalyzes the interconversion of polyols and their corresponding ketoses, and together with aldose reductase (ALDR1; MIM 103880), makes up the sorbitol pathway that is believed to play an important role in the development of diabetic complications (summarized by Carr and Markham, 1995 [PubMed 8535074]). The first reaction of the pathway (also called the polyol pathway) is the reduction of glucose to sorbitol by ALDR1 with NADPH as the cofactor. SORD then oxidizes the sorbitol to fructose using NAD(+) cofactor.

Concentration: 0.78 mg/mL

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Immunogen: Fusion protein of human SORD

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Purification Method: Antigen affinity purification

Dilution: IHC 1:50-1:100, ELISA 1:5000-1:10000

Clone: N/A

Conjugation: Unconjugated

Molecular Weight(Calculated): N/A

Molecular Weight(Observed): N/A