LBD
SOX10 Antibody (Center) [APR11289G]
- SKU:
- LBD-APR11289G
- Availability:
- Usually ships in 5 working days
Description
SOX10 Antibody (Center) [APR11289G] | Gentaur UK, US & Europe Distribution
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H, M, Rat
Specificity: This SOX10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 231-259 amino acids of human SOX10.
Cellular Localisation: Cytoplasm. Nucleus. Mitochondrion outer membrane {ECO:0000250|UniProtKB:Q04888}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q04888}; Cytoplasmic side {ECO:0000250|UniProtKB:Q04888}
Molecular Weight: 49911
Clone: Polyclonal
Gene Name: SOX10
Gene ID: 6663
Function: Transcription factor that plays a central role in developing and mature glia (By similarity) . Specifically activates expression of myelin genes, during oligodendrocyte (OL) maturation, such as DUSP15 and MYRF, thereby playing a central role in oligodendrocyte maturation and CNS myelination (By similarity) . Once induced, MYRF cooperates with SOX10 to implement the myelination program (By similarity) . Transcriptional activator of MITF, acting synergistically with PAX3 (PubMed:21965087) . Transcriptional activator of MBP, via binding to the gene promoter (By similarity) .
Summary: Tissue Location: Expressed in fetal brain and in adult brain, heart, small intestine and colon
Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.
Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.
Application: WB, IHC-P
Dilution: IHC-P--1:100~500 WB--1:2000
Synonyms: Transcription factor SOX-10, SOX10