SOX10 Antibody (Center) [APR11289G]

SOX10 Antibody (Center) [APR11289G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H, M, Rat

Specificity: This SOX10 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 231-259 amino acids of human SOX10.

Cellular Localisation: Cytoplasm. Nucleus. Mitochondrion outer membrane {ECO:0000250|UniProtKB:Q04888}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q04888}; Cytoplasmic side {ECO:0000250|UniProtKB:Q04888}

Molecular Weight: 49911

Clone: Polyclonal

Gene Name: SOX10

Gene ID: 6663

Function: Transcription factor that plays a central role in developing and mature glia (By similarity) . Specifically activates expression of myelin genes, during oligodendrocyte (OL) maturation, such as DUSP15 and MYRF, thereby playing a central role in oligodendrocyte maturation and CNS myelination (By similarity) . Once induced, MYRF cooperates with SOX10 to implement the myelination program (By similarity) . Transcriptional activator of MITF, acting synergistically with PAX3 (PubMed:21965087) . Transcriptional activator of MBP, via binding to the gene promoter (By similarity) .

Summary: Tissue Location: Expressed in fetal brain and in adult brain, heart, small intestine and colon

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB, IHC-P

Dilution: IHC-P--1:100~500 WB--1:2000

Synonyms: Transcription factor SOX-10, SOX10