SOX15 Antibody (Center) [APR30960G]

SOX15 Antibody (Center) [APR30960G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H, M

Specificity: This SOX15 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 96-125 amino acids from the Central region of human SOX15.

Cellular Localisation: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00267}.

Molecular Weight: 25251

Clone: Polyclonal

Gene Name: SOX15

Gene ID: 6665

Function: Transcription factor that binds to DNA at the 5'-AACAATG-3' consensus sequence (By similarity) . Acts as a transcriptional activator and repressor (By similarity) . Binds synergistically with POU5F1 (OCT3/4) to gene promoters (By similarity) . Binds to the FOXK1 promoter and recruits FHL3, resulting in transcriptional activation of FOXK1 which leads to myoblast proliferation (By similarity) . Acts as an inhibitor of myoblast differentiation via transcriptional repression which leads to down-regulation of the muscle-specific genes MYOD and MYOG (By similarity) . Involved in trophoblast giant cell differentiation via enhancement of HAND1 transcriptional activity (By similarity) . Regulates transcription of HRC via binding to it proximal enhancer region (By similarity) . Involved in skeletal muscle regeneration (By similarity) . Also plays a role in the development of myogenic precursor cells (By similarity) .

Summary: Tissue Location: Widely expressed in fetal and adult tissues examined, highest level found in fetal spinal cord and adult brain and testis.

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: IHC-P, WB

Dilution: WB--1:1000 IHC-P--1:100~500

Synonyms: Protein SOX-15, Protein SOX-12, Protein SOX-20, SOX15, SOX12, SOX20, SOX26, SOX27