SOX2 Antibody (N-term) [APR13461G]

SOX2 Antibody (N-term) [APR13461G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This SOX2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 30-63 amino acids from the N-terminal region of human SOX2.

Cellular Localisation: Nucleus {ECO:0000250|UniProtKB:P48432}.

Molecular Weight: 34310

Clone: Polyclonal

Gene Name: SOX2

Gene ID: 6657

Function: Transcription factor that forms a trimeric complex with OCT4 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206 (By similarity) . Binds to the proximal enhancer region of NANOG (By similarity) . Critical for early embryogenesis and for embryonic stem cell pluripotency (PubMed:18035408) . Downstream SRRT target that mediates the promotion of neural stem cell self-renewal (By similarity) . Keeps neural cells undifferentiated by counteracting the activity of proneural proteins and suppresses neuronal differentiation (By similarity) . May function as a switch in neuronal development (By similarity) .

Summary: N/A

Form: N/A

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: WB, IF

Dilution: IF--1:25 WB--1:1000

Synonyms: Transcription factor SOX-2, SOX2