Spautin-1 | 2037

Cell-permeable. A specific and potent autophagy inhibitor in mammalian cells. It promotes the degradation of Vps34 PI3 kinase complexes by inhibiting two ubiquitin specific peptidases, USP10 and USP13, that target the Beclin1 subunit of Vps34 complexes. Spautin-1 blocks the prosurvival autophagy pathway in cancer cells.

Spautin-1 is a specific and potent autophagy inhibitor in mammalian cells. It promotes the degradation of Vps34 PI3 kinase complexes by inhibiting two ubiquitin specific peptidases, USP10 and USP13, that target the Beclin1 subunit of Vps34 complexes. Spautin-1 blocks the prosurvival autophagy pathway in cancer cells.

2037 | Spautin-1 DataSheet

Alternate Name/Synonyms: 6-Fluoro-N-(4-fluorobenzyl)quinozaline-4-amine

Appearance: White solid

Formulation: N/A

CAS Number: 1262888-28-7

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₅H₁₁F₂N₃

Molecular Weight: 271.26

Cell-Permeable?: No

Purity: ≥97% by HPLC

Solubilities: DMSO (~ 100 mM)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: An USP10 and USP13 inhibitor

MDL Number: N/A

PubChem CID: N/A

SMILES: N/A

InChi: N/A

InChi Key: N/A