Specificity Protein 1 Antibody (SP1)| F41459-0.08ML

Specificity Protein 1 Antibody (SP1)| F41459-0.08ML | Gentaur UK, US & Europe Distribution

Background: Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Binds also the PDGFR-alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter. Plays an essential role in the regulation of FE65 gene expression. [UniProt]

Format: Antigen affinity purified

Clone: N/A

Host Animal: Rabbit

Clonality: Polyclonal (rabbit origin)

Isotype: Rabbit Ig

Species Reactivity: Human

Predicted Spacies Reactivity: Mouse, Rat

Application: WB, IHC, FACS, IF, ELISA

Application Details: Western blot: 1:1000, IHC (Paraffin): 1:50-1:100, Flow Cytometry: 1:10-1:50, Immunofluorescence: 1:10-1:50

Application Note: Titration of the SP1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Status: Available

Buffer: N/A

Limitation: This SP1 antibody is available for research use only.

Purity: Antigen affinity

Immunogen: A portion of amino acids 677-707 from the human protein was used as the immunogen for this SP1 antibody.

Storage: Aliquot the SP1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Localization: N/A