Sphingosine Kinase Inhibitor, SKI-I | 2046

Cell-permeable. SKI-I is a non-lipid pan-sphingosine kinase (SK) inhibitor that inhibits both SK1 and SK2 to suppress the production of pro-mitogenic sphingosine 1-phosphate (S1P) and promote cell death. Also induces autophagy.

Sphingosine Kinase Inhibitor, SKI-I is a non-lipid pan-sphingosine kinase (SK) inhibitor that inhibits both SK1 and SK2 to suppress the production of pro-mitogenic sphingosine 1-phosphate (S1P) and promote cell death. Also induces autophagy.

2046 | Sphingosine Kinase Inhibitor, SKI-I DataSheet

Alternate Name/Synonyms: 5-naphthalen-2-yl-2H-pyrazole-3-carboxylic acid (2-hydroxy-naphthalen-1-ylmethylene)-hydrazide

Appearance: Pale yellow solid

Formulation: N/A

CAS Number: 306301-68-8

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₅H₁₈N₄O₂

Molecular Weight: 406.44

Cell-Permeable?: Yes

Purity: ≥90% by NMR

Solubilities: DMSO

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A non-lipid sphingosine kinase (SK) inhibitor

MDL Number: N/A

PubChem CID: N/A

SMILES: O=C(N/N=C/C1C2CCCCC2CCC1O)C3CC(NN3)C4CCC5CCCCC5C4

InChi: InChI=1S/C25H18N4O2/c30-24-12-11-17-6-3-4-8-20(17)21(24)15-26-29-25(31)23-14-22(27-28-23)19-10-9-16-5-1-2-7-18(16)13-19/h1-15,30H,(H,27,28)(H,29,31)/b26-15+

InChi Key: XOXCTLAKMCIWCF-CVKSISIWSA-N