SPHK1 polyclonal Antibody | BS91277

SPHK1 polyclonal Antibody | BS91277 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Application: WB IHC FC

Application Range: WB:1:500-1:1,000 IHC:1:50-1:200 FC:1:50

Background: Sphingosine kinase (SphK or SphK1) is a key enzyme catalyzing the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP or S1P) . Competitive inhibitors of SphK1 block formation of SPP and selectively inhibit cellular proliferation induced by a variety of factors. One potent inhibitor of SphK1 activity is DMS (N,N-dimethylsphingosine) . SPP/SphK1 has been implicated as a signaling pathway that regulates diverse cellular functions, including cell growth, proliferation and survival. Specifically, SphK1 is involved in the signaling pathway (s) that protects human hepatocytes from the apoptotic action of TNFα. Furthermore, SPP/SphK1 may play an important role in neuronal survival by regulating activation of SAPKs and caspases. SphK1 is widely expressed with highest levels in adult liver, kidney, heart and skeletal muscle; however, activation of SphK1 disengages cells from their liver-specific phenotype.

Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: SPHK1 polyclonal Antibody detects endogenous levels of SPHK1 protein.

Molecular Weight: 51 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: SK 1, SPK 1, SPHK1, SPHK, SPK, SK 1, SK1, Sphingosine kinase 1, SPHK 1, SPHK, Sphk1, SPHK1, SPK, SPK 1,

Immunogen: recombinant protein

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: ProA affinity purified

Pathway: B cell receptor signaling,