BW
SPHK1 polyclonal Antibody | BS91277
- SKU:
- BW-BS91277
- Availability:
- Usually ships in 5 working days
Description
SPHK1 polyclonal Antibody | BS91277 | Gentaur UK, US & Europe Distribution
Host: Rabbit
Reactivity: Human, Mouse, Rat
Application: WB IHC FC
Application Range: WB:1:500-1:1,000 IHC:1:50-1:200 FC:1:50
Background: Sphingosine kinase (SphK or SphK1) is a key enzyme catalyzing the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP or S1P) . Competitive inhibitors of SphK1 block formation of SPP and selectively inhibit cellular proliferation induced by a variety of factors. One potent inhibitor of SphK1 activity is DMS (N,N-dimethylsphingosine) . SPP/SphK1 has been implicated as a signaling pathway that regulates diverse cellular functions, including cell growth, proliferation and survival. Specifically, SphK1 is involved in the signaling pathway (s) that protects human hepatocytes from the apoptotic action of TNFα. Furthermore, SPP/SphK1 may play an important role in neuronal survival by regulating activation of SAPKs and caspases. SphK1 is widely expressed with highest levels in adult liver, kidney, heart and skeletal muscle; however, activation of SphK1 disengages cells from their liver-specific phenotype.
Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Specificity: SPHK1 polyclonal Antibody detects endogenous levels of SPHK1 protein.
Molecular Weight: 51 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: SK 1, SPK 1, SPHK1, SPHK, SPK, SK 1, SK1, Sphingosine kinase 1, SPHK 1, SPHK, Sphk1, SPHK1, SPK, SPK 1,
Immunogen: recombinant protein
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: ProA affinity purified
Pathway: B cell receptor signaling,