SPINK1 polyclonal Antibody | BS6149

SPINK1 polyclonal Antibody | BS6149 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human

Application: IF

Application Range: IF 1:50 - 1:200

Background: This is a trypsin inhibitor, its physiological function is to prevent the trypsin-catalyzed premature activation of zymogens within the pancreas. Defects in SPINK1 are a cause of pancreatitis (PCTT) [MIM:167800]. A disease characterized by the presence of calculi in pancreatic ducts. It causes severe abdominal pain attacks. Defects in SPINK1 are the cause of susceptibility to tropical calcific pancreatitis (TCP) [MIM:608189]. TCP is an idiopathic, juvenile, nonalcoholic form of chronic pancreatitis widely prevalent in several tropical countries. It can be associated with fibrocalculous pancreatic diabetes (FCPD) depending on both environmental and genetic factors. TCP differs from alcoholic pancreatitis by a much younger age of onset, pancreatic calcification, a high incidence of insulin dependent but ketosis resistant diabetes mellitus, and an exceptionally high incidence of pancreatic cancer.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: SPINK1 polyclonal Antibody detects endogenous levels of SPINK1 protein.

Molecular Weight: ~ 8 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: ISK1; Pancreatic secretory trypsin inhibitor; PCTT; PSTI; Serine protease inhibitor Kazal type 1; Serine protease inhibitor Kazal-type 1; Spink 3; SPINK1; Spink3; TaTI; Tumor associated trypsin inhibitor; Tumor-associated trypsin inhibitor;

Immunogen: Recombinant full length Human SPINK1.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

Pathway: