SPTA1 Polyclonal Antibody | E-AB-19527

SPTA1 Polyclonal Antibody | E-AB-19527 | Gentaur UK, US & Europe Distribution

Type: Polyclonal Antibody

Synonyms: Alpha I spectrin, EL 2, EL2, Elliptocytosis 2, Elliptocytosis2, Erythrocyte alpha spectrin, erythrocyte, Erythroid alpha spectrin, Erythroid alpha-spectrin, Erythroid spectrin alpha, HPP, HS3, Spectrin alpha chain, Spectrin alpha chain erythrocyte, Spectrin alpha erythrocytic 1, SPH3, SPTA 1, SPTA, SPTA1, SPTA1

Application: WB, IHC, ELISA

Reactivity: Human, Mouse

Host: Rabbit

Isotype: IgG

Reserch Areas: Cancer, Cardiovascular, Signal transduction

Background: Spectrin is an actin crosslinking and molecular scaffold protein that links the plasma membrane to the actin cytoskeleton, and functions in the determination of cell shape, arrangement of transmembrane proteins, and organization of organelles. It is a tetramer made up of alpha-beta dimers linked in a head-to-head arrangement. This gene is one member of a family of alpha-spectrin genes. The encoded protein is primarily composed of 22 spectrin repeats which are involved in dimer formation. It forms weaker tetramer interactions than non-erythrocytic alpha spectrin, which may increase the plasma membrane elasticity and deformability of red blood cells. Mutations in this gene result in a variety of hereditary red blood cell disorders, including elliptocytosis type 2, pyropoikilocytosis, and spherocytic hemolytic anemia.

Concentration: 1.7 mg/mL

Storage: Store at -20°C. Avoid freeze / thaw cycles.

Immunogen: Synthetic peptide of human SPTA1

Buffer: PBS with 0.05% NaN3 and 40% Glycerol, pH7.4

Purification Method: Antigen affinity purification

Dilution: WB 1:500-1:2000, IHC 1:60-1:450, ELISA 1:5000-1:10000

Clone: N/A

Conjugation: Unconjugated

Molecular Weight(Calculated): 280 kDa

Molecular Weight(Observed): Refer to figures