SPTLC1 Antibody (C-term) [APR07187G]

SPTLC1 Antibody (C-term) [APR07187G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This SPTLC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 405-437 amino acids from the C-terminal region of human SPTLC1.

Cellular Localisation: Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:O35704}; Single-pass membrane protein {ECO:0000250|UniProtKB:O35704}

Molecular Weight: 52744

Clone: Polyclonal

Gene Name: SPTLC1

Gene ID: 10558

Function: Serine palmitoyltransferase (SPT) (PubMed:19416851) . The heterodimer formed with SPTLC2 or SPTLC3 constitutes the catalytic core (PubMed:19416851) . The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference (PubMed:19416851) . The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA (PubMed:19416851) . The SPTLC1-SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability to use a broader range of acyl-CoAs, without apparent preference (PubMed:19416851) . Required for adipocyte cell viability and metabolic homeostasis (By similarity) .

Summary: Tissue Location: Widely expressed. Not detected in small intestine.

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Serine palmitoyltransferase 1, Long chain base biosynthesis protein 1, LCB 1, Serine-palmitoyl-CoA transferase 1, SPT 1, SPT1, SPTLC1, LCB1