SPTLC3 Antibody (C-Term) [APR32891G]

SPTLC3 Antibody (C-Term) [APR32891G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This SPTLC3 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 503-545 amino acids from human SPTLC3.

Cellular Localisation: Endoplasmic reticulum membrane; Single-pass membrane protein

Molecular Weight: 62049

Clone: Polyclonal

Gene Name: SPTLC3 (HGNC:16253)

Gene ID: 55304

Function: Serine palmitoyltransferase (SPT) . The heterodimer formed with LCB1/SPTLC1 constitutes the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. SPT complexes containing SPTLC3 generate shorter chain sphingoid bases compared to complexes containing SPTLC2. The SPTLC1- SPTLC3-SPTSSA isozyme uses C12-CoA, C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA. On the other hand, the SPTLC1- SPTLC3-SPTSSB has the ability to use a broader range of acyl-CoAs without apparent preference.

Summary: Tissue Location: Expressed in most tissues, except peripheral blood cells and bone marrow, with highest levels in heart, kidney, liver, uterus and skin.

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: WB

Dilution: WB--1:2000

Synonyms: Serine palmitoyltransferase 3, 2.3.1.50, Long chain base biosynthesis protein 2b, LCB2b, Long chain base biosynthesis protein 3, LCB 3, Serine-palmitoyl-CoA transferase 3, SPT 3, SPTLC3, C20orf38, SPTLC2L