Description
An ATP-competitive, serine/arginine-rich protein kinase (SRPK)-specific inhibitor (Ki = 0.89 µM for SRPK1). SRPIN 340 does not inhibit other classes of Serine-Arginine-Rich Protein Kinases (SRPKs) significantly, including Clk1 and Clk4 and >140 other SR kinases. SRPIN340 also suppresses VEGF expression and attenuates choroidal neovascularization (CNV).
SRPIN340 is an ATP-competitive, serine/arginine-rich protein kinase (SRPK)-specific inhibitor (Ki = 0.89 µM for SRPK1).
Alternate Name/Synonyms: N-[2-(1-piperidinyl)-5-(trifluoromethyl)phenyl]isonicotinamide; SRPK Inhibitor
Appearance: Light yellow solid
Formulation: N/A
CAS Number: 218156-96-8
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: No
Molecular Formula: C₁₈H₁₈F₃N₃O
Molecular Weight: 349.35
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (~100 mg/ml)
Handling: Protect from air and light
Country of Origin: USA
Tag Line: A SRPK inhibitor
MDL Number: N/A
PubChem CID: N/A
SMILES: O=C(C1=CC=NC=C1)NC2=CC(C(F)(F)F)=CC=C2N3CCCCC3
InChi: InChI=1S/C18H18F3N3O/c19-18(20,21)14-4-5-16(24-10-2-1-3-11-24)15(12-14)23-17(25)13-6-8-22-9-7-13/h4-9,12H,1-3,10-11H2,(H,23,25)
InChi Key: DWFGGOFPIISJIT-UHFFFAOYSA-N
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
24 months |