SRPIN340 | 2458

An ATP-competitive, serine/arginine-rich protein kinase (SRPK)-specific inhibitor (Ki = 0.89 µM for SRPK1). SRPIN 340 does not inhibit other classes of Serine-Arginine-Rich Protein Kinases (SRPKs) significantly, including Clk1 and Clk4 and >140 other SR kinases. SRPIN340 also suppresses VEGF expression and attenuates choroidal neovascularization (CNV).

SRPIN340 is an ATP-competitive, serine/arginine-rich protein kinase (SRPK)-specific inhibitor (Ki = 0.89 µM for SRPK1).

2458 | SRPIN340 DataSheet

Alternate Name/Synonyms: N-[2-(1-piperidinyl)-5-(trifluoromethyl)phenyl]isonicotinamide; SRPK Inhibitor

Appearance: Light yellow solid

Formulation: N/A

CAS Number: 218156-96-8

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₈H₁₈F₃N₃O

Molecular Weight: 349.35

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (~100 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A SRPK inhibitor

MDL Number: N/A

PubChem CID: N/A

SMILES: O=C(C1=CC=NC=C1)NC2=CC(C(F)(F)F)=CC=C2N3CCCCC3

InChi: InChI=1S/C18H18F3N3O/c19-18(20,21)14-4-5-16(24-10-2-1-3-11-24)15(12-14)23-17(25)13-6-8-22-9-7-13/h4-9,12H,1-3,10-11H2,(H,23,25)

InChi Key: DWFGGOFPIISJIT-UHFFFAOYSA-N