LBD
SRY Antibody (N-Term) [ApR04847G]
- SKU:
- LBD-ApR04847G
- Availability:
- Usually ships in 5 working days
Description
SRY Antibody (N-Term) [ApR04847G] | Gentaur UK, US & Europe Distribution
Product Category: Polyclonal Antibodies
Host: Rabbit
Species Reactivity: H
Specificity: This SRY antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 52-82 amino acids from human SRY.
Cellular Localisation: Nucleus speckle. Cytoplasm. Nucleus Note=Acetylation contributes to its nuclear localization and deacetylation by HDAC3 induces a cytoplasmic delocalization (PubMed:15297880) . Colocalizes with SOX6 in speckles (PubMed:11818535) Colocalizes with CAML in the nucleus (PubMed:15746192) . Colocalizes in the nucleus with ZNF208 isoform KRAB-O and tyrosine hydroxylase (TH) (By similarity) . {ECO:0000250|UniProtKB:Q05738, ECO:0000269|PubMed:11818535, ECO:0000269|PubMed:15297880, ECO:0000269|PubMed:15746192}
Molecular Weight: 23884
Clone: Polyclonal
Gene Name: SRY {ECO:0000303|PubMed:1695712, ECO:0000312|HGNC:HGNC:11311}
Gene ID: 6736
Function: Transcriptional regulator that controls a genetic switch in male development (PubMed:11563911) . It is necessary and sufficient for initiating male sex determination by directing the development of supporting cell precursors (pre-Sertoli cells) as Sertoli rather than granulosa cells (PubMed:16996051, PubMed:16414182) . Involved in different aspects of gene regulation including promoter activation or repression (PubMed:9525897) . Binds to the DNA consensus sequence 5'- [AT]AACAA[AT]-3' (PubMed:1425584, PubMed:8265659, PubMed:8159753, PubMed:11563911, PubMed:15170344) . SRY HMG box recognizes DNA by partial intercalation in the minor groove and promotes DNA bending (PubMed:1425584, PubMed:8265659, PubMed:8159753, PubMed:11563911, PubMed:15170344, PubMed:16762365) . Also involved in pre-mRNA splicing (PubMed:11818535) . In male adult brain involved in the maintenance of motor functions of dopaminergic neurons (By similarity) .
Summary: N/A
Form: N/A
Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.
Application: WB
Dilution: WB--1:2000
Synonyms: Sex-determining region Y protein, Testis-determining factor, SRY, TDF