Description
SSR128129E (SSR) is a potent small molecule, allosteric inhibitor of FGFR signaling. SSR binds to the extracellular part of the receptor and it does not compete with FGF for binding to FGFR but inhibits FGF-induced signaling linked to FGFR internalization in an allosteric manner.
SSR128129E (SSR) is a potent small molecule, allosteric inhibitor of FGFR signaling. SSR binds to the extracellular part of the receptor and it does not compete with FGF for binding to FGFR but inhibits FGF-induced signaling linked to FGFR internalization in an allosteric manner.
Alternate Name/Synonyms: 2-Amino-5-(1-methoxy-2-methylindolizine-3-carbonyl)benzoate sodium salt
Appearance: Yellow Solid
Formulation: N/A
CAS Number: 848318-25-2
Structure Available?: Yes
Peptide sequence: N/A
Salt Form: Yes
Molecular Formula: C₁₈H₁₅N₂NaO₄
Molecular Weight: 346.31
Cell-Permeable?: Yes
Purity: ≥98% by HPLC
Solubilities: DMSO (>30 mg/ml)
Handling: Protect from air and moisture
Country of Origin: USA
Tag Line: SSR128129E (SSR) is a potent FGFR inhibitor
MDL Number: N/A
PubChem CID: 68853159
SMILES: CC1=C(N2C=CC=CC2=C1OC)C(=O)C3=CC(=C(C=C3)N)C(=O)[O-].[Na+
InChi: 1S/C18H16N2O4.Na/c1-10-15(20-8-4-3-5-14(20)17(10)24-2)16(21)11-6-7-13(19)12(9-11)18(22)23;/h3-9H,19H2,1-2H3,(H,22,23);/q;+1/p-1
InChi Key: JFBMSTWZURKQOC-UHFFFAOYSA-M
Additional Information
Storage Condition: |
-20°C |
Shipping Condition: |
Gel Pack |
Shelf Life: |
36 months |