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ST3Gal1, soluble fragment, Human Recombinant | P1224
- SKU:
- 26-P1224-GEN
- Availability:
- Usually shipped in 5 working days
Description
ST3Gal1 catalyzes transfer of the sialic acid Neu5Ac from CMP-Neu5Ac (cytidine 5'-monophosphono-N-acetylneuraminic acid) to Gal1, 3GalNAc on glycoproteins or glycolipids in an 2, 3 linkage. It is a type II transmembrane protein that is normally localized to the golgi, but can be cleaved to yield a soluble product. Sialylation of the core-1 structure (Gal1, 3GalNAc-O-Ser/Thr) by ST3Gal1 prevents formation of the core-2 structure (GlcNAc1, 6(Gal1, 3)GalNAc-Ser/Thr). On CD8+ T-cells this prevents induction of either apoptosis or differentiation into memory cells. Overexpression of ST3Gal1 in breast cancer cells correlated with the presence of the core-1 based marker SM3, whereas healthy cells displayed a higher ratio of core-2 based epitopes. Overexpression of ST3Gal1 in colorectal carcinoma was found to be related to poor patient survival.
P1224 | ST3Gal1 soluble fragment Human Recombinant DataSheet
Biomolecule/Target: ST3Gal1
Synonyms: CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1, Gal-NAc6S, Gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferase, SIATFL, ST3Gal I
Alternates names: CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1, Gal-NAc6S, Gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferase, SIATFL, ST3Gal I
Taglines: Involved in the pathway protein glycosylation, which is part of Protein modification
NCBI Gene ID #: 28106
NCBI Gene Symbol: CS010
Gene Source: Human
Accession #: Q9CPT4
Recombinant: Yes
Source: Insect cells
Purity by SDS-PAGEs: 97%
Assay: SDS-PAGE
Purity: N/A
Assay #2: N/A
Endotoxin Level: N/A
Activity (Specifications/test method): N/A
Biological activity: N/A
Results: N/A
Binding Capacity: N/A
Unit Definition: N/A
Molecular Weight: 45 kDa
Concentration: 100 ug/ml
Appearance: Liquid
Physical form description: Sterile filtered solution in 25 mM Tris pH 7.5 and 150 mM NaCl
Reconstitution Instructions: Reconstitute in sterile ddHO to a concentration 100 µg/ml. This solution can then be diluted into other aqueous buffers.
Amino acid sequence: MVSEPTTVPF DVRPGGVVHS FSQDVGPGNK FTCTFTYASQ GGTNEQWQMS LGTSEDSQHF TCTIWRPQGK SYLYFTQFKA ELRGAEIEYA MAYSKAAFER ESDVPLKSEE FEVTKTAVSH RPGAFKAELS KLVIVAKAAR SEL