ST3GAL2 Antibody (N-term) [APR32973G]

ST3GAL2 Antibody (N-term) [APR32973G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This ST3GAL2 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 55-89 amino acids from the N-terminal region of human ST3GAL2.

Cellular Localisation: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Secreted. Note=Membrane-bound form distributed along the Golgi cisternae, mainly in proximal compartments (PubMed:25916169) . Secreted into the body fluid. {ECO:0000250, ECO:0000269|PubMed:25916169}

Molecular Weight: 40173

Clone: Polyclonal

Gene Name: ST3GAL2 (HGNC:10863)

Gene ID: 6483

Function: A beta-galactoside alpha2-3 sialyltransferase primarily involved in terminal sialylation of ganglio and globo series glycolipids (PubMed:8920913, PubMed:9266697) . Catalyzes the transfer of sialic acid (N-acetyl-neuraminic acid; Neu5Ac) from the nucleotide sugar donor CMP-Neu5Ac onto acceptor Galbeta- (1->3) -GalNAc-terminated glycoconjugates through an alpha2-3 linkage (PubMed:8920913, PubMed:9266697, PubMed:25916169) . Sialylates GM1/GM1a, GA1/asialo-GM1 and GD1b gangliosides to form GD1a, GM1b and GT1b, respectively (PubMed:8920913, PubMed:9266697) . Together with ST3GAL3, primarily responsible for biosynthesis of brain GD1a and GT1b that function as ligands for myelin-associated glycoprotein MAG on axons, regulating MAG expression and axonal myelin stability and regeneration (By similarity) . Via GT1b regulates TLR2 signaling in spinal cord microglia in response to nerve injury (By similarity) . Responsible for the sialylation of the pluripotent stem cell- and cancer stem cell- associated antigen SSEA3, forming SSEA4 (PubMed:12716912) . Sialylates with low efficiency asialofetuin, presumably onto O-glycosidically linked Galbeta- (1->3) -GalNAc-O-Ser (PubMed:9266697, PubMed:25916169) .

Summary: Tissue Location: Highly expressed in skeletal muscle and heart and to a much lesser extent in brain, placenta, liver and pancreas Scarcely detectable in lung and kidney.

Form: N/A

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: CMP-N-acetylneuraminate-beta-galactosamide-alpha-2, 3-sialyltransferase 2, Alpha 2, 3-ST 2, Beta-galactoside alpha-2, 3-sialyltransferase 2, Gal-NAc6S, Gal-beta-1, 3-GalNAc-alpha-2, 3-sialyltransferase, ST3Gal II, ST3GalII, ST3GalA2, Sialyltransferase 4B, SIAT4-B, ST3GAL2, SIAT4B