STAT1 (Phospho-S727) polyclonal Antibody | BS94034

STAT1 (Phospho-S727) polyclonal Antibody | BS94034 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human, Mouse, Rat

Application: WB IHC

Application Range: WB:1:1,000 IHC:1:50-1:200

Background: Membrane receptor signaling by various ligands, including interferons and growth hormones such as EGF, induces activation of Jak kinases which then leads to tyrosine phosphorylation of the various Stat transcription factors. Stat1 and Stat2 are induced by IFN-a and form a heterodimer which is part of the ISGF3 transcription factor complex. Although early reports indicate Stat3 activation by EGF and IL-6, it has been shown that Stat3β appears to be activated by both while Stat3α is activated by EGF, but not by IL-6. Highest expression of Stat4 is seen in testis and myeloid cells. IL-12 has been identified as an activator of Stat4. Stat5 has been shown to be activated by prolactin and by IL-3. Stat6 is involved in IL-4 activated signaling pathways.

Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: STAT1 (Phospho-S727) polyclonal Antibody detects endogenous levels of STAT1 protein only when phosphorylated at S727.

Molecular Weight: 87 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: STAT1, Signal transducer and activator of transcription 1 91kD, CANDF7, DKFZp686B04100, IMD31A, IMD31B, IMD31C, ISGF 3, ISGF-3, OTTHUMP00000163552, OTTHUMP00000165046, OTTHUMP00000165047, OTTHUMP00000205845, Signal transducer and activator of transcription 1 91kDa, Signal transducer and activator of transcription 1, Signal transducer and activator of transcription 1, 91kD, Signal transducer and activator of transcription 1-alpha/beta, STAT 1, Stat1, STAT1, STAT91, Transcription factor ISGF 3 components p91 p84, Transcription factor ISGF-3 components p91/p84,

Immunogen: Synthetic phospho-peptide corresponding to residues surrounding Ser727 of human STAT1.

Conjugate: Unconjugated

Modification: Phosphorylation

Purification & Purity: ProA affinity purified

Pathway: