STAT4 polyclonal Antibody | BS91287

STAT4 polyclonal Antibody | BS91287 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human

Application: WB ICC/IF IHC IP FC

Application Range: WB:1:1,000 ICC:1:100-1:500 IHC:1:50-1:200 FC:1:50-1:100

Background: Membrane receptor signaling by various ligands, including interferons and growth hormones such as EGF, induces activation of Jak kinases which then leads to tyrosine phosphorylation of the various Stat transcription factors. Stat1 and Stat2 are induced by IFN-a and form a heterodimer which is part of the ISGF3 transcription factor complex. Although early reports indicate Stat3 activation by EGF and IL-6, it has been shown that Stat3β appears to be activated by both while Stat3α is activated by EGF, but not by IL-6. Highest expression of Stat4 is seen in testis and myeloid cells. IL-12 has been identified as an activator of Stat4. Stat5 has been shown to be activated by prolactin and by IL-3. Stat6 is involved in IL-4 activated signaling pathways.

Storage & Stability: Store at +4°C after thawing. Aliquot store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

Specificity: STAT4 polyclonal Antibody detects endogenous levels of STAT4 protein.

Molecular Weight: 86 kDa

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: STAT4, Signal transducer and activator of transcription 4, SLEB11, STAT4, STAT4,

Immunogen: recombinant protein

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: ProA affinity purified

Pathway: T cell receptor signaling,