Stat5a monoclonal Antibody | MB65273

Stat5a monoclonal Antibody | MB65273 | Gentaur UK, US & Europe Distribution

Host: Mouse

Reactivity: Human, Mouse, Rat

Application: IHC, WB

Application Range: WB 1:200~500, IHC 1:50

Background: Stat5a is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for the tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X (L), which suggests the antiapoptotic function of this gene in cells.

Storage & Stability: PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Specificity: signal transducer and activator of transcription 5A

Molecular Weight: 90.5 kDa (Predicted)

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: MGF; STAT5

Immunogen: Human recombinant protein fragment corresponding to amino acids 2-104 of human Stat5a (NP_003143) produced in E.coli.

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)

Pathway: N/A