STF-62247 | B2210

STF-62247 is a small molecule agonist that induces autophagy and selectively causes lethality in renal cell carcinoma (RCC) cells that have lost the von Hippel-Lindau (VHL) tumor suppressor activity (IC₅₀ = 625 nM). STF-62247 induces cytotoxicity and reduces tumor growth of VHL-deficient RCC cells compared to genetically matched cells with wild-type VHL.

STF-62247 is a small molecule agonist that induces autophagy and selectively causes lethality in renal cell carcinoma (RCC) cells that have lost the von Hippel-Lindau (VHL) tumor suppressor activity (IC₅₀ = 625 nM). STF-62247 induces cytotoxicity and reduces tumor growth of VHL-deficient RCC cells compared to genetically matched cells with wild-type VHL.

B2210 | STF-62247 DataSheet

Alternate Name/Synonyms: N-(3-Methylphenyl)-4-(4-pyridinyl)-2-thiazolamine

Appearance: Off-white solid

Formulation: N/A

CAS Number: 315702-99-9

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₅H₁₃N₃S

Molecular Weight: 267.35

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>25 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: An autophagy inducer and an anticancer agent

MDL Number: N/A

PubChem CID: 704473

SMILES: CC1=CC(=CC=C1)NC2=NC(=CS2)C3=CC=NC=C3

InChi: InChI=1S/C15H13N3S/c1-11-3-2-4-13(9-11)17-15-18-14(10-19-15)12-5-7-16-8-6-12/h2-10H,1H3,(H,17,18)

InChi Key: KATNUHQNJGNLPW-UHFFFAOYSA-N