STOML2 Antibody (Center) [APR04539G]

STOML2 Antibody (Center) [APR04539G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This STOML2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 161-189 amino acids from the Central region of human STOML2.

Cellular Localisation: Cell membrane; Peripheral membrane protein. Mitochondrion. Mitochondrion inner membrane; Lipid-anchor. Mitochondrion intermembrane space. Membrane raft. Cytoplasm, cytoskeleton Note=Behaves as an integral membrane protein of the mitochondrion despite the absence of a detectable transmembrane domain (PubMed:21746876) . Also associates with the actin cytoskeleton and membrane rafts in activated T-cells (PubMed:18641330, PubMed:10713127) A minor pool is associated with the plasma membrane and is enriched at the immunological synapse in activated T-cells (PubMed:22623988)

Molecular Weight: 38534

Clone: Polyclonal

Gene Name: STOML2

Gene ID: 30968

Function: Mitochondrial protein that probably regulates the biogenesis and the activity of mitochondria. Stimulates cardiolipin biosynthesis, binds cardiolipin-enriched membranes where it recruits and stabilizes some proteins including prohibitin and may therefore act in the organization of functional microdomains in mitochondrial membranes. Through regulation of the mitochondrial function may play a role into several biological processes including cell migration, cell proliferation, T-cell activation, calcium homeostasis and cellular response to stress. May play a role in calcium homeostasis through negative regulation of calcium efflux from mitochondria. Required for mitochondrial hyperfusion a pro-survival cellular response to stress which results in increased ATP production by mitochondria. May also regulate the organization of functional domains at the plasma membrane and play a role in T-cell activation through association with the T- cell receptor signaling complex and its regulation.

Summary: Tissue Location: Ubiquitously expressed at low levels. Expressed in lymphoid tissues (at protein level) .

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Stomatin-like protein 2, mitochondrial, SLP-2, EPB72-like protein 2, Paraprotein target 7, Paratarg-7, STOML2, SLP2