STRA8 Antibody (C-term) [APR30790G]

STRA8 Antibody (C-term) [APR30790G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This STRA8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 286-315 amino acids from the C-terminal region of human STRA8.

Cellular Localisation: Cytoplasm {ECO:0000250|UniProtKB:P70278}. Nucleus {ECO:0000250|UniProtKB:P70278}. Note=Shuttles between nucleus and cytoplasm. Nuclear export is XPO1-dependent {ECO:0000250|UniProtKB:P70278}

Molecular Weight: 36908

Clone: Polyclonal

Gene Name: STRA8 (HGNC:30653)

Gene ID: 346673

Function: Meiosis-inducer required for the transition into meiosis for both female and male germ cells. In female germ cells, acts downstream of ZGLP1 as a key effector of the meiotic program: required for premeiotic DNA replication and subsequent events in meiotic prophase. During spermatogenesis, next to its role in meiotic initiation, promotes (but is not required for) spermatogonial differentiation. In complex with MEIOSIN, directly activates the transcription of a subset of critical meiotic genes playing a central role in cell-cycle switching from mitosis to meiosis.

Summary: Tissue Location: Expressed specifically in testis and fetal ovaries.

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: IHC-P-Leica, WB

Dilution: IHC-P-Leica--1:250 WB--1:2000

Synonyms: Stimulated by retinoic acid gene 8 protein homolog, STRA8 {ECO:0000312|EMBL:AAP471631}