800
STUB1 Antibody| F40135-0.08ML/F40135-0.4ML/R33375-100UG
- SKU:
- 800-F40135-0.08ML/800-F40135-0.4ML/800-R33375-100UG
- Availability:
- Usually ships in 5 working days
Description
STUB1 Antibody| F40135-0.08ML/F40135-0.4ML/R33375-100UG | Gentaur UK, US & Europe Distribution
Background: CHIP is an E3 ligase for nNOS whose action is facilitated by (and possibly requires) its interaction with nNOS-bound hsp70. Co-chaperone CHIP, possibly with another E3 ligase(s), modulates the ubiquitylation of mutant Cu/Zn-superoxide dismutase and renders them more susceptible for proteasomal degradation. CHIP functions as a negative regulator of AR transcriptional activity by promoting AR degradation. CHIP-Hsc70 complex ubiquitinates phosphorylated tau and enhances cell survival. CHIP can interact with the Smad1/Smad4 proteins and block BMP signal transduction through the ubiquitin-mediated degradation of Smad proteins. CHIP E3 controls both the association of Hsp70/Hsp90 chaperones with ErbB2 and the down-regulation of ErbB2 induced by inhibitors of Hsp90. CHIP is associated with Parkin and enhances its ubiquitin ligase activity related to Parkinson's disease.
Format: Antigen affinity purified
Clone: N/A
Host Animal: Rabbit
Clonality: Polyclonal (rabbit origin)
Isotype: Rabbit Ig
Species Reactivity: Human
Predicted Spacies Reactivity: Mouse, Chicken
Application: IHC, WB, ELISA
Application Details: Western blot: 1:1000, IHC (Paraffin): 1:50-1:100
Application Note: Titration of the STUB1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Status: Available
Buffer: N/A
Limitation: This STUB1 antibody is available for research use only.
Purity: Antigen affinity
Immunogen: A portion of amino acids 203-231 from the human protein was used as the immunogen for this STUB1 antibody.
Storage: Aliquot the STUB1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Localization: N/A