SUR1 Polyclonal Antibody | BS65637

SUR1 Polyclonal Antibody | BS65637 | Gentaur UK, US & Europe Distribution

Host: Rabbit

Reactivity: Human,Mouse,Rat,Dog,Pig,Horse,Guinea Pig,

Application: WB,

Application Range: WB=1:500-2000

Background: SUR1 is a member of ATP binding cassette super family. SUR receptor confers the sensitivity of Kir6.2 to ATP/ADP sensitivity and to pharmacological agents such as sulfonylurea and diazoxide that close or open the KATP channels. The persistent heyperinsulinimic hypoglycemia in infancy (PHHI) is familial disorder due to defect in negative feed back in response to low glucose levels. SUR1 was mapped on chromosome 11p14-15.1, the same location where the gene for PHHI is located. It has been shown that the expression of Kir6.2 and SUR1 are regulated by glucose levels and the actives of glucogon like peptide receptor 1. Abnormal insulin secretion in PHHI appears to be caused by mutations in the SUR gene.

Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.

Specificity: SUR1 Polyclonal Antibody detects endogenous levels of SUR1 protein.

Molecular Weight: 175 kD

Note: For research use only, not for use in diagnostic procedure.

Alternative Names: ABC36; Abcc8; ATP binding cassette sub family C (CFTR/MRP) member 8; ATP binding cassette transporter sub family C member 8 (1) ; HHF1; HRINS; MRP8; PHHI; Sulfonylurea receptor 1; SUR.

Immunogen: KLH conjugated synthetic peptide derived from human SUR1

Conjugate: Unconjugated

Modification: Unmodification

Purification & Purity: affinity purified by Protein A

Pathway: