SURF4 Antibody (C-term) [APR31716G]

SURF4 Antibody (C-term) [APR31716G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: M

Specificity: This SURF4 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 211-237 amino acids from the C-terminal region of human SURF4.

Cellular Localisation: Endoplasmic reticulum membrane; Multi-pass membrane protein. Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi- pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Note=Cycles between the endoplasmic reticulum and the Golgi.

Molecular Weight: 30394

Clone: Polyclonal

Gene Name: SURF4 {ECO:0000303|PubMed:18287528, ECO:0000312|HGNC:HGNC:11476}

Gene ID: 6836

Function: Endoplasmic reticulum cargo receptor that mediates the export of lipoproteins by recruiting cargos into COPII vesicles to facilitate their secretion (PubMed:30251625, PubMed:29643117, PubMed:33186557) . Acts as a cargo receptor for lipoproteins bearing both APOB and APOA1, thereby regulating lipoprotein delivery and the maintenance of lipid homeostasis (PubMed:29643117, PubMed:33186557) . Synergizes with the GTPase SAR1B to mediate transport of circulating lipoproteins (PubMed:33186557) . Promotes the secretion of PCSK9 (PubMed:30251625) . Also mediates the efficient secretion of erythropoietin (EPO) (PubMed:32989016) . May also play a role in the maintenance of the architecture of the endoplasmic reticulum-Golgi intermediate compartment and of the Golgi (PubMed:18287528) .

Summary: N/A

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000

Synonyms: Surfeit locus protein 4, SURF4, SURF-4