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Survivin Rabbit monoclonal Antibody | BS9870M
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- BW-BS9870M
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Description
Survivin Rabbit monoclonal Antibody | BS9870M | Gentaur UK, US & Europe Distribution
Host: Rabbit
Reactivity: Mouse, Rat
Application: WB IHC
Application Range: WB: 1:1000-1:2000 IHC: 1:50-1:200
Background: Two mammalian homologs of baculovirus p35, referred to as inhibitor of apoptosis protein (IAP) 1 and 2, share an amino-terminal baculovirus IAP repeat (BIR) motif and a carboxy-terminal RING finger. Although the c-IAPs do not directly associate with the TNF receptor (TNF-R), they efficiently block TNF-mediated apoptosis through their interaction with the downstream TNF-R effectors, TRAF1 and TRAF2. Additional IAP family members include ILP (for IAP-like protein) and survivin. ILP inhibits activated caspase-3, leading to the resistance of FASmediated apoptosis. Survivin (also designated TIAP) is expressed during the G2/M phase of the cell cycle and associates with microtubules of the mitotic spindle. Increased caspase-3 activity is detected when a disruption of survivinmicrotubule interactions occurs.
Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: This Antibody detects endogenous levels of Survivin and does not cross-react with related proteins.
Molecular Weight: ~ 16 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: Survivin; Apoptosis inhibitor survivin; Apoptosis inhibitor 4; BIRC5; API4; IAP4
Immunogen: Recombinant Antibody.
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: Protein A affinity purified
Pathway: