SUV4-20H1 Antibody (N-term) [APR31034G]

SUV4-20H1 Antibody (N-term) [APR31034G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H

Specificity: This SUV4-20H1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 21-54 amino acids from the N-terminal region of human SUV4-20H1.

Cellular Localisation: Nucleus. Chromosome. Note=Associated with pericentric heterochromatin. CBX1 and CBX5 are required for the localization to pericentric heterochromatin (By similarity) .

Molecular Weight: 99188

Clone: Polyclonal

Gene Name: KMT5B (HGNC:24283)

Gene ID: 51111

Function: Histone methyltransferase that specifically methylates monomethylated 'Lys-20' (H4K20me1) and dimethylated 'Lys-20' (H4K20me2) of histone H4 to produce respectively dimethylated 'Lys-20' (H4K20me2) and trimethylated 'Lys-20' (H4K20me3) and thus regulates transcription and maintenance of genome integrity (PubMed:24396869, PubMed:28114273) . In vitro also methylates unmodified 'Lys-20' (H4K20me0) of histone H4 and nucleosomes (PubMed:24396869) . H4 'Lys-20' trimethylation represents a specific tag for epigenetic transcriptional repression. Mainly functions in pericentric heterochromatin regions, thereby playing a central role in the establishment of constitutive heterochromatin in these regions. KMT5B is targeted to histone H3 via its interaction with RB1 family proteins (RB1, RBL1 and RBL2) (By similarity) . Plays a role in myogenesis by regulating the expression of target genes, such as EID3 (PubMed:23720823) . Facilitates TP53BP1 foci formation upon DNA damage and proficient non-homologous end-joining (NHEJ) -directed DNA repair by catalyzing the di- and trimethylation of 'Lys-20' of histone H4 (PubMed:28114273) . May play a role in class switch reconbination by catalyzing the di- and trimethylation of 'Lys- 20' of histone H4 (By similarity) .

Summary: N/A

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB, FC

Dilution: WB--1:1000 FC--1:10~50

Synonyms: Histone-lysine N-methyltransferase SUV420H1, Lysine N-methyltransferase 5B, Suppressor of variegation 4-20 homolog 1, Su (var) 4-20 homolog 1, Suv4-20h1, SUV420H1, KMT5B