SW-044248 | B1135

SW-044248 is a selective Topoisomerase I inhibitor. It is extremely potent and selectively toxic to NSCLC killing ~15% of a 74 NSCLC cell lines. It was not toxic to immortalized human bronchial cell lines. The intense transcriptional response to SW-044248 in HCC4017 cells significantly correlates to topoisomerase-I inhibition and not topoisomerase-II.

SW-044248 is a selective Topoisomerase I inhibitor. It is extremely potent and selectively toxic to NSCLC killing ~15% of a 74 NSCLC cell lines. It was not toxic to immortalized human bronchial cell lines. The intense transcriptional response to SW-044248 in HCC4017 cells significantly correlates to topoisomerase-I inhibition and not topoisomerase-II.

B1135 | SW-044248 DataSheet

Alternate Name/Synonyms: 2-((5-ethyl-5H-[1,2,4]triazino[5,6-b]indol-3-yl)thio)-N-(2-methoxyphenyl)butanamide

Appearance: Yellow Solid

Formulation: N/A

CAS Number: 522650-83-5

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₂H₂₃N₅O₂S

Molecular Weight: 421.51

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (>40 mg/ml)

Handling: Protect from air and light

Country of Origin: USA

Tag Line: A potent and selective Topoisomerase I inhibitor.

MDL Number: N/A

PubChem CID: 3152990

SMILES: CCC(C(=O)NC1=CC=CC=C1OC)SC2=NC3=C(C4=CC=CC=C4N3CC)N=N2

InChi: 1S/C22H23N5O2S/c1-4-18(21(28)23-15-11-7-9-13-17(15)29-3)30-22-24-20-19(25-26-22)14-10-6-8-12-16(14)27(20)5-2/h6-13,18H,4-5H2,1-3H3,(H,23,28)

InChi Key: PEVRGVRHMMZNGI-UHFFFAOYSA-N