Syk Inhibitor II | B2918

Syk Inhibitor II is an ATP-competitive inhibitor of spleen tyrosine kinase (Syk) with an IC₅₀ of 41 nM. It is much less potent against PKCε, PKCβII, ZAP-70, Btk, and Itk. It prevents FcεRI-mediated 5-HT release in RBL-2H3 cells in vitro and inhibits passive cutaneous anaphylaxis reactions in mice, with an ID₅₀ of 13 mg/kg following subcutaneous administration.

Syk Inhibitor II is an ATP-competitive inhibitor of spleen tyrosine kinase (Syk) with an IC₅₀ of 41 nM. It is much less potent against PKCε, PKCβII, ZAP-70, Btk, and Itk. It prevents FcεRI-mediated 5-HT release in RBL-2H3 cells in vitro and inhibits passive cutaneous anaphylaxis reactions in mice, with an ID₅₀ of 13 mg/kg following subcutaneous administration.

B2918 | Syk Inhibitor II DataSheet

Alternate Name/Synonyms: 2-(2-aminoethylamino)-4-[3-(trifluoromethyl)anilino]pyrimidine-5-carboxamide; K00592a; 2-[(2-aminoethyl)amino]-4-[[3-(trifluoromethyl)phenyl]amino]-5-pyrimidinecarboxamide

Appearance: Solid

Formulation:

CAS Number: 726695-51-8

Structure Available?: True

Peptide sequence:

Salt Form: false

Molecular Formula: C₁₄H₁₅F₃N₆O

Molecular Weight: 340.3

Cell-Permeable?: True

Purity: 95%

Solubilities: ~15 mg/ml in in DMSO, ~25 mg/ml in DMF in 0

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: An inhibitor of spleen tyrosine kinase (Syk)

MDL Number:

PubChem CID: 9549296

SMILES: C1=CC(=CC(=C1)NC2=NC(=NC=C2C(=O)N)NCCN)C(F)(F)F

InChi: InChI=1S/C14H15F3N6O/c15-14(16,17)8-2-1-3-9(6-8)22-12-10(11(19)24)7-21-13(23-12)20-5-4-18/h1-3,6-7H,4-5,18H2,(H2,19,24)(H2,20,21,22,23)

InChi Key: