SYNE3 Antibody (C-term) [APR30683G]

SYNE3 Antibody (C-term) [APR30683G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H, M

Specificity: This SYNE3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 852-880 amino acids from the C-terminal region of human SYNE3.

Cellular Localisation: Nucleus outer membrane; Single-pass type IV membrane protein. Nucleus envelope. Rough endoplasmic reticulum

Molecular Weight: 112216

Clone: Polyclonal

Gene Name: SYNE3 (HGNC:19861)

Gene ID: 161176

Function: As a component of the LINC (LInker of Nucleoskeleton and Cytoskeleton) complex involved in the connection between the nuclear lamina and the cytoskeleton. The nucleocytoplasmic interactions established by the LINC complex play an important role in the transmission of mechanical forces across the nuclear envelope and in nuclear movement and positioning. Probable anchoring protein which tethers the nucleus to the cytoskeleton by binding PLEC which can associate with the intermediate filament system. Plays a role in the regulation of aortic epithelial cell morphology, and is required for flow-induced centrosome polarization and directional migration in aortic endothelial cells.

Summary: Tissue Location: Expressed in aortic endothelial cells (at protein level) .

Form: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purified through a protein A column, followed by peptide affinity purification.

Storage: Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles.

Application: WB, IHC-P

Dilution: WB--1:1000 IHC-P--1:100~500

Synonyms: Nesprin-3, Nuclear envelope spectrin repeat protein 3, SYNE3, C14orf49