SYNJ1 Antibody (C-term) [APR13630G]

SYNJ1 Antibody (C-term) [APR13630G] | Gentaur UK, US & Europe Distribution

Product Category: Polyclonal Antibodies

Host: Rabbit

Species Reactivity: H, M, Rat

Specificity: This SYNJ1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 1148-1182 amino acids from the C-terminal region of human SYNJ1.

Cellular Localisation: Cytoplasm, perinuclear region {ECO:0000250|UniProtKB:O18964}

Molecular Weight: 173103

Clone: Polyclonal

Gene Name: SYNJ1

Gene ID: 8867

Function: Phosphatase that acts on various phosphoinositides, including phosphatidylinositol 4-phosphate, phosphatidylinositol (4, 5) - bisphosphate and phosphatidylinositol (3, 4, 5) -trisphosphate (PubMed:27435091) . Has a role in clathrin-mediated endocytosis (By similarity) . Hydrolyzes PIP2 bound to actin regulatory proteins resulting in the rearrangement of actin filaments downstream of tyrosine kinase and ASH/GRB2 (By similarity) .

Summary: Tissue Location: Concentrated at clathrin-coated endocytic intermediates in nerve terminals. Isoform 1 is more enriched than isoform 2 in developing brain as well as non-neuronal cells. Isoform 2 is very abundant in nerve terminals

Form: N/A

Storage: Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

Application: WB

Dilution: WB--1:1000-1:2000

Synonyms: Synaptojanin-1, Synaptic inositol 1, 5-trisphosphate 5-phosphatase 1, SYNJ1, KIAA0910