BW
Synuclein-pan (A19) polyclonal Antibody | BS1349
- SKU:
- BW-BS1349
- Availability:
- Usually ships in 5 working days
Description
Synuclein-pan (A19) polyclonal Antibody | BS1349 | Gentaur UK, US & Europe Distribution
Host: Rabbit
Reactivity: Human,Mouse,Rat
Application: WB IHC
Application Range: WB: 1:500~1:1000 IHC: 1:50~1:200
Background: The synuclein family members, including α-synuclein (also designated NACP for non-β amyloid component) and β-synuclein, are predominantly expressed in the brain and are speculated to be involved in synaptic regulation and neuronal plasticity. α-synuclein is localized to neuronal cell bodies and synapses. α-synuclein was first identified as a component of Alzheimer’s disease amyloid plaques. Abnormal platelet function in Alzheimer’s disease has been demonstrated. During megakaryocytic differentiation α-synuclein was found to be up-regulated, while β-synuclein is down-regulated, indicating that coordinate expression of synucleins may be important during hematopoetic cell differentiation. A mutant form of α-synuclein has been found in patients with early onset Parkinson’s disease.
Storage & Stability: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze-thaw cycles.
Specificity: Synuclein-pan (A19) polyclonal Antibody detects endogenous levels of Synuclein-pan (α-synuclein, β-synuclein, γ-synuclein) protein.
Molecular Weight: ~ 18 kDa
Note: For research use only, not for use in diagnostic procedure.
Alternative Names: Alpha-synuclein; α-synuclein; Non-A beta component of AD amyloid; Non-A4 component of amyloid precursor; NACP; SNCA; NACP; PARK1; Beta-synuclein; SNCB; β-synuclein; synuclein-β; Gamma-synuclein; γ-synuclein; synuclein-γ; Breast cancer-specific gene 1 protein; Persyn; Synoretin; SR; SNCG; BCSG1; PERSYN; PRSN
Immunogen: Synthetic peptide, corresponding to amino acids N-terminus of 19-30 Synuclein-α.
Conjugate: Unconjugated
Modification: Unmodification
Purification & Purity: The Antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .
Pathway: Neuronal and Glial Cell Marker Atlas,Amyloid Plaque and Neurofibrillary Tangle Formation in Alzheimer's Disease,