SYVN1 Antibody (HRD1)| F40119-0.08ML/F40119-0.4ML

SYVN1 Antibody (HRD1)| F40119-0.08ML/F40119-0.4ML | Gentaur UK, US & Europe Distribution

Background: HRD1/SYVN1 is a ubiquitin ligase whose expression is induced by the unfolded protein response (UPR) following endoplasmic reticulum stress. Expression of SYVN1 protects cells from apoptosis by inducing degradation of abnormally processed proteins that accumulate in the endoplasmic reticulum. It is expressed in many tissues, strongly expressed in brain, pancreas, liver, kidney and skeletal muscle. Amano T, et al. reported that Synoviolin/Hrd1 (expressed in rheumatoid synovium) is a novel causative factor for arthropathy by triggering synovial cell outgrowth through its antiapoptotic effects.

Format: Purified

Clone: N/A

Host Animal: Rabbit

Clonality: Polyclonal (rabbit origin)

Isotype: Rabbit Ig

Species Reactivity: Human, Mouse

Predicted Spacies Reactivity: N/A

Application: IF, IHC, WB, ELISA

Application Details: Western blot: 1:200-1000, IHC (Paraffin): 1:50-1:100

Application Note: Titration of the SYVN1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Status: Available

Buffer: N/A

Limitation: This SYVN1 antibody is available for research use only.

Purity: Purified

Immunogen: A portion of amino acids 586-617 from the human protein was used as the immunogen for this SYVN1 antibody.

Storage: Aliquot the SYVN1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Localization: N/A