800
SYVN1 Antibody (HRD1)| F40119-0.08ML/F40119-0.4ML
- SKU:
- 800-F40119-0.08ML/800-F40119-0.4ML
- Availability:
- Usually ships in 5 working days
Description
SYVN1 Antibody (HRD1)| F40119-0.08ML/F40119-0.4ML | Gentaur UK, US & Europe Distribution
Background: HRD1/SYVN1 is a ubiquitin ligase whose expression is induced by the unfolded protein response (UPR) following endoplasmic reticulum stress. Expression of SYVN1 protects cells from apoptosis by inducing degradation of abnormally processed proteins that accumulate in the endoplasmic reticulum. It is expressed in many tissues, strongly expressed in brain, pancreas, liver, kidney and skeletal muscle. Amano T, et al. reported that Synoviolin/Hrd1 (expressed in rheumatoid synovium) is a novel causative factor for arthropathy by triggering synovial cell outgrowth through its antiapoptotic effects.
Format: Purified
Clone: N/A
Host Animal: Rabbit
Clonality: Polyclonal (rabbit origin)
Isotype: Rabbit Ig
Species Reactivity: Human, Mouse
Predicted Spacies Reactivity: N/A
Application: IF, IHC, WB, ELISA
Application Details: Western blot: 1:200-1000, IHC (Paraffin): 1:50-1:100
Application Note: Titration of the SYVN1 antibody may be required due to differences in protocols and secondary/substrate sensitivity.
Status: Available
Buffer: N/A
Limitation: This SYVN1 antibody is available for research use only.
Purity: Purified
Immunogen: A portion of amino acids 586-617 from the human protein was used as the immunogen for this SYVN1 antibody.
Storage: Aliquot the SYVN1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Localization: N/A