SZL-P1-41 | B3325

SZL P1-41 is a specific Skp2 inhibitor that binds to the F-box domain of Skp2 to prevent Skp1 association and Skp2 SCF complex formation. Also inhibits Skp2-mediated p27 and Akt ubiquitination in vivo and in vitro. Suppresses the survival of cancer cells and cancer stem cells by triggering cell senescence and inhibiting glycolysis. Displays antitumor effects in multiple animal models and cancer cell lines.

SZL P1-41 is a specific Skp2 inhibitor that binds to the F-box domain of Skp2 to prevent Skp1 association and Skp2 SCF complex formation. Also inhibits Skp2-mediated p27 and Akt ubiquitination in vivo and in vitro. Suppresses the survival of cancer cells and cancer stem cells by triggering cell senescence and inhibiting glycolysis. Displays antitumor effects in multiple animal models and cancer cell lines.

B3325 | SZL-P1-41 DataSheet

Alternate Name/Synonyms: 3-(2-Benzothiazolyl)-6-ethyl-7-hydroxy-8-(1-piperidinylmethyl)-4H-1-benzopyran-4-one

Appearance: Off-white solid

Formulation:

CAS Number: 222716-34-9

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₂₄H₂₄N₂O₃S

Molecular Weight: 420.52

Cell-Permeable?: TRUE

Purity: ≥98% by HPLC

Solubilities: ~2 mg/ml DMSO

Handling: Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.

Country of Origin: USA

Tag Line: A selective Skp2 inhibitor

MDL Number:

PubChem CID: 1286902

SMILES: OC(C(CC)=C2)=C(CN3CCCCC3)C1=C2C(C(C4=NC5=C(C=CC=C5)S4)=CO1)=O

InChi: InChI=1S/C24H24N2O3S/c1-2-15-12-16-22(28)18(24-25-19-8-4-5-9-20(19)30-24)14-29-23(16)17(21(15)27)13-26-10-6-3-7-11-26/h4-5,8-9,12,14,27H,2-3,6-7,10-11,13H2,1H3

InChi Key: JKIXLEKBXHMXTN-UHFFFAOYSA-N