Talabostat mesylate | B2061

Talabostat is a nonselective inhibitor of post-proline cleaving serine proteases. The inhibition of the highly related cytosolic serine proteases Dpp8 and Dpp9 (Dpp8/9) by Val-boroPro was recently demonstrated to trigger an immunostimulatory form of programmed cell death known as pyroptosis selectively in monocytes and macrophages. Talabostat induces powerful anti-tumor immune responses in syngeneic cancer models.

Talabostat is a nonselective inhibitor of post-proline cleaving serine proteases. The inhibition of the highly related cytosolic serine proteases Dpp8 and Dpp9 (Dpp8/9) by Val-boroPro was recently demonstrated to trigger an immunostimulatory form of programmed cell death known as pyroptosis selectively in monocytes and macrophages. Talabostat induces powerful anti-tumor immune responses in syngeneic cancer models.

B2061 | Talabostat mesylate DataSheet

Alternate Name/Synonyms: (R)-1-((S)-2-amino-3-methylbutanoyl)pyrrolidin-2-ylboronic acid methanesulfonic acid ; PT-100; Val-boro-pro

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 150080-09-4

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₁₀H₂₃BN₂OS

Molecular Weight: 310.17

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: A nonselective inhibitor of post-proline cleaving serine proteases

MDL Number: N/A

PubChem CID: 11522448

SMILES: B(C1CCCN1C(=O)C(C(C)C)N)(O)O.CS(=O)(=O)O

InChi: InChI=1S/C9H19BN2O3.CH4O3S/c1-6(2)8(11)9(13)12-5-3-4-7(12)10(14)15;1-5(2,3)4/h6-8,14-15H,3-5,11H2,1-2H3;1H3,(H,2,3,4)/t7-,8-;/m0./s1

InChi Key: OXYYOEIGQRXGPI-WSZWBAFRSA-N