Tandutinib | 2024

Cell-permeable. A potent inhibitor of Fms-like tyrosine kinase 3 (FLT3) kinase, PDGFRβ and c-Kit (IC50’s 95-122 ng/ml). It inhibits FLT3 phosphorylation, downstream signaling and tumor growth in vitro and in animal models.

Tandutinib is a potent inhibitor of Fms-like tyrosine kinase 3 (FLT3) kinase, PDGFRβ and c-Kit (IC50’s 95-122 ng/ml). It inhibits FLT3 phosphorylation, downstream signaling and tumor growth in vitro and in animal models.

2024 | Tandutinib DataSheet

Alternate Name/Synonyms: MLN518; CT53518

Appearance: White to off-white solid

Formulation: N/A

CAS Number: 387867-13-2

Structure Available?: Yes

Peptide sequence: N/A

Salt Form: No

Molecular Formula: C₃₁H₄₂N₆O₄

Molecular Weight: 562.7

Cell-Permeable?: Yes

Purity: ≥98% by HPLC

Solubilities: DMSO (~ 25 mg/ml) or EtOH (~ 25 mg/ml)

Handling: Protect from air and moisture

Country of Origin: USA

Tag Line: A potent inhibitor of FLT kinase, PDGFRβ and c-Kit

MDL Number: MFCD09954147

PubChem CID: 3038522

SMILES: CC(C)OC1=CC=C(C=C1)NC(=O)N2CCN(CC2)C3=NC=NC4=CC(=C(C=C43)OC)OCCCN5CCCCC5

InChi: InChI=1S/C31H42N6O4/c1-23(2)41-25-10-8-24(9-11-25)34-31(38)37-17-15-36 (16-18-37)30-26-20-28(39-3)29(21-27(26)32-22-33-30)40-19-7-14-35-12-5-4- 6-13-35/h8-11,20-23H,4-7,12-19H2,1-3H3,(H,34,38)

InChi Key: UXXQOJXBIDBUAC-UHFFFAOYSA-N